Difference can mean more than one thing. A difference is something that two or more things do not have in common. That is, it is something that is not the same about two things. In mathematics, the difference between two numbers is how much bigger one is than the other. Difference is the result of subtraction. Define difference. difference synonyms, difference pronunciation, difference translation, English dictionary definition of difference. disparity; unlikeness; distinction: made a difference Not to be confused with: deference – courteous respect for another’s opinion, wishes, or judgment. DIFFERENCE definition: the state or relation of being different; dissimilarity. See examples of difference used in a sentence. Synonyms for DIFFERENCE: diversity, distinctiveness, contrast, distinctness, distinction, disagreement, discrepancy, distance; Antonyms of DIFFERENCE: similarity. In cases where a writer is uncertain whether a subject (s) is singular or plural, or male or female, and (s)he wants to cover all the bases, parentheses denote that things could be one or the other. The meaning of DIFFERENCE is the quality or state of being dissimilar or different. How to use difference in a sentence. Difference commonly refers to: Difference (philosophy), the set of properties by which items are distinguished Difference (mathematics), the result of a subtraction Difference, The Difference, Differences or Differently may also refer to: DIFFERENCE definition: 1. the way in which two or more things which you are comparing are not the same: 2. a…. Learn more. The Percentage Difference Calculator (% difference calculator) will find the percent difference between two positive numbers greater than 0. Percentage difference is usually calculated when you want to know the difference in percentage between two numbers. Difference is a word for things that are not the same. Identical twins have few if any differences in appearance.